Electrogenomics Group Unravelling the electrical and genetic causes of cardiovascular mortality

Publications

The Electrogenomics Group conducts interdisciplinary research that integrates genomics and electrophysiology to uncover the molecular and genetic mechanisms underlying cardiac and vascular function. Our team has produced a series of high-impact scientific publications that significantly advance the understanding of cardiovascular biology. The current activities of the team are centred on studying complex phenotypes of cardiac electrophysiology and response to heart rate dynamics. Building on recent publications by the group, further studies are underway to improve our understanding of the mechanisms linking genetics, functional biology, electrophysiology and cardiovascular disease, and the integration of these biomarkers to optimise risk prediction of cardiac events.

Explore our latest publications to discover the groundbreaking advancements we are making in the field of electrogenomics.

Highlighted

Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways
Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways
William J. Young, Najim Lahrouchi, Aaron Isaacs, ThuyVy Duong, Luisa Foco, …, Pier D. Lambiase, Nona Sotoodehnia, Borbala Mifsud, Christopher Newton-Cheh, Patricia B. Munroe
Nature Communications  ·  01 Sep 2022  ·  doi:10.1038/s41467-022-32821-z

All

2024

Genome‐Wide Interaction Analyses of Serum Calcium on Ventricular Repolarization Time in 125 393 Participants
Genome‐Wide Interaction Analyses of Serum Calcium on Ventricular Repolarization Time in 125 393 Participants
William J. Young, Peter J. van der Most, Traci M. Bartz, Maxime M. Bos, Ginevra Biino, …, Nona Sotoodehnia, Andrew Tinker, Helen R. Warren, Raymond Noordam, Patricia B. Munroe
Journal of the American Heart Association  ·  03 Sep 2024  ·  doi:10.1161/JAHA.123.034760
The frequency of gene variant reclassification and its impact on clinical management in the inherited arrhythmia clinic
The frequency of gene variant reclassification and its impact on clinical management in the inherited arrhythmia clinic
William J. Young, Soe Maung, Selda Ahmet, Claire Kirkby, Charlotte Ives, Richard J. Schilling, Martin Lowe, Pier D. Lambiase
Heart Rhythm  ·  01 Jun 2024  ·  doi:10.1016/j.hrthm.2024.01.008

2023

Prognostic Significance of Different Ventricular Ectopic Burdens During Submaximal Exercise in Asymptomatic UK Biobank Subjects
Prognostic Significance of Different Ventricular Ectopic Burdens During Submaximal Exercise in Asymptomatic UK Biobank Subjects
Stefan van Duijvenboden, Julia Ramírez, Michele Orini, Nay Aung, Steffen E. Petersen, Aiden Doherty, Andrew Tinker, Patricia B. Munroe, Pier D. Lambiase
Circulation  ·  12 Dec 2023  ·  doi:10.1161/CIRCULATIONAHA.123.064633
Prognostic Significance of Different Ventricular Ectopic Burdens During Submaximal Exercise in Asymptomatic UK Biobank Subjects
Prognostic Significance of Different Ventricular Ectopic Burdens During Submaximal Exercise in Asymptomatic UK Biobank Subjects
Stefan van Duijvenboden, Julia Ramírez, Michele Orini, Nay Aung, Steffen E. Petersen, Aiden Doherty, Andrew Tinker, Patricia B. Munroe, Pier D. Lambiase
Circulation  ·  12 Dec 2023  ·  doi:10.1161/circulationaha.123.064633
Ultra-Short Beat-to-Beat Repolarization Variability Predicts Cardiovascular Events in Individuals without Cardiovascular Disease
Ultra-Short Beat-to-Beat Repolarization Variability Predicts Cardiovascular Events in Individuals without Cardiovascular Disease
Michele Orini, Stefan van Duijvenboden, Julia Ramírez, Will Young, Andrew Tinker, Patricia Munroe, Pier Lambiase
Computing in Cardiology Conference (CinC)  ·  26 Nov 2023  ·  doi:10.22489/cinc.2023.178
Long-term association of ultra-short heart rate variability with cardiovascular events
Long-term association of ultra-short heart rate variability with cardiovascular events
Michele Orini, Stefan van Duijvenboden, William J. Young, Julia Ramírez, Aled R. Jones, Alun D. Hughes, Andrew Tinker, Patricia B. Munroe, Pier D. Lambiase
Scientific Reports  ·  03 Nov 2023  ·  doi:10.1038/s41598-023-45988-2
Ultra-short heart rate variability over 15 seconds is associated with increased long-term risk of cardiovascular disease
Ultra-short heart rate variability over 15 seconds is associated with increased long-term risk of cardiovascular disease
M Orini, S Van Duijvenboden, W J Young, J Ramirez, A R Jones, A Tinker, P B Munroe, P D Lambiase
European Heart Journal  ·  01 Nov 2023  ·  doi:10.1093/eurheartj/ehad655.2912
Discovery of rare variants associated with resting heart rate
Discovery of rare variants associated with resting heart rate
Julia Ramirez, Stefan van Duijvenboden, Lahiru Thomas Sooriyabandara, Andrew Tinker, Patricia Munroe
European Journal of Human Genetics  ·  01 May 2023  ·  doi:10.1038/s41431-023-01338-4
Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease
Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease
William J. Young, Jeffrey Haessler, Jan-Walter Benjamins, Linda Repetto, Jie Yao, …, Nona Sotoodehnia, Borbala Mifsud, Pier D. Lambiase, Larisa G. Tereshchenko, Patricia B. Munroe
Nature Communications  ·  14 Mar 2023  ·  doi:10.1038/s41467-023-36997-w
Premature atrial and ventricular contractions detected on wearable-format electrocardiograms and prediction of cardiovascular events
Premature atrial and ventricular contractions detected on wearable-format electrocardiograms and prediction of cardiovascular events
Michele Orini, Stefan van Duijvenboden, William J Young, Julia Ramírez, Aled R Jones, Andrew Tinker, Patricia B Munroe, Pier D Lambiase
European Heart Journal - Digital Health  ·  03 Feb 2023  ·  doi:10.1093/ehjdh/ztad007

2022

Association between photoplethysmography pulse upslope and cardiovascular events in over 170,000 UK Biobank participants
Association between photoplethysmography pulse upslope and cardiovascular events in over 170,000 UK Biobank participants
Michele Orini, Stefan van Duijvenboden, Andrew Tinker, Patricia Munroe, Pier Lambiase
Computing in Cardiology Conference (CinC)  ·  31 Dec 2022  ·  doi:10.22489/cinc.2022.226
Uncoupling Between Heart Rate Variability and Heart Rate During Exercise and Recovery as a Predictor of Cardiovascular Events
Uncoupling Between Heart Rate Variability and Heart Rate During Exercise and Recovery as a Predictor of Cardiovascular Events
“Michele Orini, Stefan van Duijvenboden, Julia Ramirez, Andrew Tinker, Patricia Munroe, Pier Lambiase”
Computing in Cardiology Conference (CinC)  ·  31 Dec 2022  ·  doi:10.22489/cinc.2022.229
Prediction of Coronary Artery Disease and Major Adverse Cardiovascular Events Using Clinical and Genetic Risk Scores for Cardiovascular Risk Factors
Prediction of Coronary Artery Disease and Major Adverse Cardiovascular Events Using Clinical and Genetic Risk Scores for Cardiovascular Risk Factors
Julia Ramírez, Stefan van Duijvenboden, William J. Young, Andrew Tinker, Pier D. Lambiase, Michele Orini, Patricia B. Munroe
Circulation: Genomic and Precision Medicine  ·  01 Oct 2022  ·  doi:10.1161/circgen.121.003441
ECG T‐Wave Morphologic Variations Predict Ventricular Arrhythmic Risk in Low‐ and Moderate‐Risk Populations
ECG T‐Wave Morphologic Variations Predict Ventricular Arrhythmic Risk in Low‐ and Moderate‐Risk Populations
Julia Ramírez, Antti Kiviniemi, Stefan van Duijvenboden, Andrew Tinker, Pier D. Lambiase, Juhani Junttila, Juha S. Perkiömäki, Heikki V. Huikuri, Michele Orini, Patricia B. Munroe
Journal of the American Heart Association  ·  06 Sep 2022  ·  doi:10.1161/jaha.121.025897
Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways
Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways
William J. Young, Najim Lahrouchi, Aaron Isaacs, ThuyVy Duong, Luisa Foco, …, Pier D. Lambiase, Nona Sotoodehnia, Borbala Mifsud, Christopher Newton-Cheh, Patricia B. Munroe
Nature Communications  ·  01 Sep 2022  ·  doi:10.1038/s41467-022-32821-z

2021

Genomic and pleiotropic analyses of resting QT interval identifies novel loci and overlap with atrial electrical disorders
Genomic and pleiotropic analyses of resting QT interval identifies novel loci and overlap with atrial electrical disorders
Stefan van Duijvenboden, Julia Ramírez, William J Young, Michele Orini, Borbala Mifsud, Andrew Tinker, Pier D Lambiase, Patricia B Munroe
Human Molecular Genetics  ·  19 Jul 2021  ·  doi:10.1093/hmg/ddab197
Genetically Determined Serum Calcium Levels and Markers of Ventricular Repolarization: A Mendelian Randomization Study in the UK Biobank
Genetically Determined Serum Calcium Levels and Markers of Ventricular Repolarization: A Mendelian Randomization Study in the UK Biobank
William J. Young, Helen R. Warren, Dennis O. Mook-Kanamori, Julia Ramírez, Stefan van Duijvenboden, …, Diana van Heemst, Pier D. Lambiase, J. Wouter Jukema, Patricia B. Munroe, Raymond Noordam
Circulation: Genomic and Precision Medicine  ·  01 Jun 2021  ·  doi:10.1161/circgen.120.003231
A Novel Two-Stage Heart Arrhythmia Ensemble Classifier
A Novel Two-Stage Heart Arrhythmia Ensemble Classifier
Mercedeh J. Rezaei, John R. Woodward, Julia Ramírez, Patricia Munroe
Computers  ·  01 May 2021  ·  doi:10.3390/computers10050060
No Clinically Relevant Effect of Heart Rate Increase and Heart Rate Recovery During Exercise on Cardiovascular Disease: A Mendelian Randomization Analysis
No Clinically Relevant Effect of Heart Rate Increase and Heart Rate Recovery During Exercise on Cardiovascular Disease: A Mendelian Randomization Analysis
Josephine Mensah-Kane, Amand F. Schmidt, Aroon D. Hingorani, Chris Finan, Yutang Chen, …, Pier D. Lambiase, Andrew Tinker, Eirini Marouli, Patricia B. Munroe, Julia Ramírez
Frontiers in Genetics  ·  18 Feb 2021  ·  doi:10.3389/fgene.2021.569323
A Method to Minimise the Impact of ECG Marker Inaccuracies on the Spatial QRS-T angle: Evaluation on 1,512 Manually Annotated ECGs
A Method to Minimise the Impact of ECG Marker Inaccuracies on the Spatial QRS-T angle: Evaluation on 1,512 Manually Annotated ECGs
William J. Young, Stefan van Duijvenboden, Julia Ramírez, Aled Jones, Andrew Tinker, Patricia B. Munroe, Pier D. Lambiase, Michele Orini
Biomedical Signal Processing and Control  ·  01 Feb 2021  ·  doi:10.1016/j.bspc.2020.102305
Analysing electrocardiographic traits and predicting cardiac risk in UK biobank
Analysing electrocardiographic traits and predicting cardiac risk in UK biobank
Julia Ramírez, Stefan van Duijvenboden, William J Young, Michele Orini, Aled R Jones, Pier D Lambiase, Patricia B Munroe, Andrew Tinker
JRSM Cardiovascular Disease  ·  01 Jan 2021  ·  doi:10.1177/20480040211023664

2020

Will Genetic Data Significantly Change Cardiovascular Risk Prediction in Daily Practice?
Will Genetic Data Significantly Change Cardiovascular Risk Prediction in Daily Practice?
William Young, Julia Ramírez, Stefan van Duijvenboden, Andrew Tinker, Pier Lambiase, Patricia Munroe, Michele Orini
Computing in Cardiology Conference (CinC)  ·  30 Dec 2020  ·  doi:10.22489/CinC.2020.481
Interaction Between ECG and Genetic Markers of Coronary Artery Disease
Interaction Between ECG and Genetic Markers of Coronary Artery Disease
Julia Ramírez, Stefan van Duijvenboden, William Young, Andrew Tinker, Pier Lambiase, Patricia Munroe, Michele Orini
Computing in Cardiology Conference (CinC)  ·  30 Dec 2020  ·  doi:10.22489/CinC.2020.478
Sex Differences in the Morphology of RR-Matched T-waves
Sex Differences in the Morphology of RR-Matched T-waves
Julia Ramírez, Stefan van Duijvenboden, Andrew Tinker, Pier Lambiase, Patricia Munroe, Michele Orini
Computing in Cardiology Conference (CinC)  ·  30 Dec 2020  ·  doi:10.22489/CinC.2020.402
Interaction Between ECG and Genetic Markers of Coronary Artery Disease
Interaction Between ECG and Genetic Markers of Coronary Artery Disease
Julia Ramírez, Stefan van Duijvenboden, William Young, Andrew Tinker, Pier Lambiase, Patricia Munroe, Michele Orini
Computing in Cardiology Conference (CinC)  ·  30 Dec 2020  ·  doi:10.22489/cinc.2020.478
Sex Differences in the Morphology of RR-Matched T-waves
Sex Differences in the Morphology of RR-Matched T-waves
Julia Ramírez, Stefan van Duijvenboden, Andrew Tinker, Pier Lambiase, Patricia Munroe, Michele Orini
Computing in Cardiology Conference (CinC)  ·  30 Dec 2020  ·  doi:10.22489/cinc.2020.402
Ventricular Restitution Predicts Paroxysmal Atrial Fibrillation in Horses
Ventricular Restitution Predicts Paroxysmal Atrial Fibrillation in Horses
Julia Ramírez, Andrew Tinker
Function  ·  09 Nov 2020  ·  doi:10.1093/function/zqaa038
Data Augmentation for Heart Arrhythmia Classification
Data Augmentation for Heart Arrhythmia Classification
Mercedeh J. Rezaei, John R. Woodward, Julia Ramirez, Patricia Munroe
2020 IEEE 32nd International Conference on Tools with Artificial Intelligence (ICTAI)  ·  01 Nov 2020  ·  doi:10.1109/ICTAI50040.2020.00145
Genetic Determinants of Electrocardiographic P-Wave Duration and Relation to Atrial Fibrillation
Genetic Determinants of Electrocardiographic P-Wave Duration and Relation to Atrial Fibrillation
Lu-Chen Weng, Amelia Weber Hall, Seung Hoan Choi, Sean J. Jurgens, Jeffrey Haessler, …, Charles Kooperberg, Emelia J. Benjamin, Kathryn L. Lunetta, Patrick T. Ellinor, Steven A. Lubitz
Circulation: Genomic and Precision Medicine  ·  01 Oct 2020  ·  doi:10.1161/circgen.119.002874
Genetic Basis and Prognostic Value of Exercise QT Dynamics
Genetic Basis and Prognostic Value of Exercise QT Dynamics
Stefan van Duijvenboden, Julia Ramírez, William J. Young, Borbala Mifsud, Michele Orini, Andrew Tinker, Patricia B. Munroe, Pier D. Lambiase
Circulation: Genomic and Precision Medicine  ·  01 Aug 2020  ·  doi:10.1161/circgen.119.002774
Common Genetic Variants Modulate the Electrocardiographic Tpeak-to-Tend Interval
Common Genetic Variants Modulate the Electrocardiographic Tpeak-to-Tend Interval
Julia Ramírez, Stefan van Duijvenboden, William J. Young, Michele Orini, Pier D. Lambiase, Patricia B. Munroe, Andrew Tinker
The American Journal of Human Genetics  ·  01 Jun 2020  ·  doi:10.1016/j.ajhg.2020.04.009
Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction
Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction
Ioanna Ntalla, Lu-Chen Weng, James H. Cartwright, Amelia Weber Hall, Gardar Sveinbjornsson, …, Kari Stefansson, Patrick T. Ellinor, Yalda Jamshidi, Steven A. Lubitz, Patricia B. Munroe
Nature Communications  ·  21 May 2020  ·  doi:10.1038/s41467-020-15706-x
Real Time Non-Invasive Hemodynamic Assessment of Ventricular Tachycardia
Real Time Non-Invasive Hemodynamic Assessment of Ventricular Tachycardia
Tudor Besleaga, Pier D. Lambiase, Adam J. Graham, Andreas Demosthenous, Michele Orini
IEEE Access  ·  01 Jan 2020  ·  doi:10.1109/access.2020.3012494

2019

Cardiovascular Predictive Value and Genetic Basis of Ventricular Repolarization Dynamics
Cardiovascular Predictive Value and Genetic Basis of Ventricular Repolarization Dynamics
Julia Ramírez, Stefan van Duijvenboden, Nay Aung, Pablo Laguna, Esther Pueyo, Andrew Tinker, Pier D. Lambiase, Michele Orini, Patricia B. Munroe
Circulation: Arrhythmia and Electrophysiology  ·  01 Oct 2019  ·  doi:10.1161/circep.119.007549
Resting Heart Rate and Type 2 Diabetes
Resting Heart Rate and Type 2 Diabetes
Patricia B. Munroe, Julia Ramírez, Stefan van Duijvenboden
Journal of the American College of Cardiology  ·  01 Oct 2019  ·  doi:10.1016/j.jacc.2019.08.1030
Genome-wide association study identifies loci for arterial stiffness index in 127,121 UK Biobank participants
Genome-wide association study identifies loci for arterial stiffness index in 127,121 UK Biobank participants
Kenneth Fung, Julia Ramírez, Helen R. Warren, Nay Aung, Aaron M. Lee, Evan Tzanis, Steffen E. Petersen, Patricia B. Munroe
Scientific Reports  ·  24 Jun 2019  ·  doi:10.1038/s41598-019-45703-0

2018

Assessing a Warping Methodology for the Identification of Increased Cardiovascular Risk Based on the HR Profile Morphology
Assessing a Warping Methodology for the Identification of Increased Cardiovascular Risk Based on the HR Profile Morphology
Julia Ramírez, Stefan van Duijvenboden, Pablo Laguna, Esther Pueyo, Andrew Tinker, Pier Lambiase, Patricia Munroe, Michele Orini
Computing in Cardiology Conference (CinC)  ·  30 Dec 2018  ·  doi:10.22489/cinc.2018.039
Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6
Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6
Bram P. Prins, Timothy J. Mead, Jennifer A. Brody, Gardar Sveinbjornsson, Ioanna Ntalla, …, Kari Stefansson, Patricia B. Munroe, Dan E. Arking, Cecilia W. Lo, Yalda Jamshidi
Genome Biology  ·  17 Jul 2018  ·  doi:10.1186/s13059-018-1457-6
Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system
Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system
Julia Ramírez, Stefan van Duijvenboden, Ioanna Ntalla, Borbala Mifsud, Helen R Warren, Evan Tzanis, Michele Orini, Andrew Tinker, Pier D. Lambiase, Patricia B. Munroe
Nature Communications  ·  16 May 2018  ·  doi:10.1038/s41467-018-04148-1

2017

Long-term intra-individual reproducibility of heart rate dynamics during exercise and recovery in the UK Biobank cohort
Long-term intra-individual reproducibility of heart rate dynamics during exercise and recovery in the UK Biobank cohort
Michele Orini, Andrew Tinker, Patricia B. Munroe, Pier D. Lambiase
PLOS ONE  ·  05 Sep 2017  ·  doi:10.1371/journal.pone.0183732
The mechanisms of ventricular arrhythmia in Chagas disease
The mechanisms of ventricular arrhythmia in Chagas disease
Andrew Tinker
International Journal of Cardiology  ·  01 Aug 2017  ·  doi:10.1016/j.ijcard.2017.03.094
Heritability of resting heart rate and association with mortality in middle-aged and elderly twins
Heritability of resting heart rate and association with mortality in middle-aged and elderly twins
Patricia B Munroe, Andrew Tinker
Heart  ·  28 Jun 2017  ·  doi:10.1136/heartjnl-2017-311657
Discovery of novel heart rate-associated loci using the Exome Chip
Discovery of novel heart rate-associated loci using the Exome Chip
Marten E. van den Berg, Helen R. Warren, Claudia P. Cabrera, Niek Verweij, Borbala Mifsud, …, Charles Kooperberg, Pim van der Harst, Mark Eijgelsheim, Bruno H. Stricker, Patricia B. Munroe
Human Molecular Genetics  ·  03 Apr 2017  ·  doi:10.1093/hmg/ddx113